• PKA signalling in the http www apexbt com

  2025-01-15

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the Peptide 17 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and fun

• br Occurrence of Inosine in RNA Inosine is

  2025-01-14

  

  Occurrence of Inosine in RNA Inosine is widespread among various types of RNAs including transfer RNA (tRNA), ribosomal RNA (rRNA), messenger RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA). Within these RNAs, inosine can appear in different locations as well. Table 1 lists examples

• The following are the supplementary data related to this art

  2025-01-14

  

  The following are the supplementary data related to this article. Funding Work in Dr. Rosell's laboratory is partially supported by a grant from La Caixa Foundation, and an Instituto de Salud Carlos III grant (RESPONSE, PIE16/00011). Work in Dr. Cao's laboratory is partially supported by the Maj

• br Research perspective In vitro and in vivo

  2025-01-14

  

  Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron

• The R pycnus arginase was identical to the

  2025-01-14

  

  The R. pycnus arginase was 65% identical to the published B. caldovelox arginase sequence (AAB06939). Furthermore, the R. pycnus arginase gene was 62%, 45%, 36% and 22% identical to the published arginase sequences from Bacillus thuringiensis (AJI37018), Thermus thermophiles (WP_038039155), Human ar

• Within the thrombus there is heterogeneity in the

  2025-01-13

  

  Within the thrombus, there is heterogeneity in the activation of nuciferine based on the concentration gradients of soluble agonists emanating from the site of vascular injury, which has been excellently reviewed by Tomaiuolo et al.[1]. As part of the coagulation cascade, active thrombin is generat

• Estudos de biomarcadores mostram que as concentra es de

  2025-01-13

  

  Estudos de biomarcadores mostram que as concentrações de proteína amiloide no LCR estão inversamente relacionadas com o grau de doença de Alzheimer. No entanto, quer as placas amiloides quer a diminuição da proteína amiloide podem ser encontradas em idosos sem clínica de disfunção cognitiva, pelo qu

• CAY10433 br Materials and Methods br Results In the

  2025-01-13

  

  Materials and Methods Results In the Base Analysis (53% of patients having access to the ALK test in both Current and Alternative Scenarios), a total of 16,583 patients were tested of whom 1,252 were assumed to be ALK-positive. A more extensive use of Ventana in the Alternative Scenario determ

• br Conflict of interest statement br Introduction Human sali

  2025-01-13

  

  Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant trk inhibitor like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic aldehydes contained in f

• Subsequently Palvimaki et al corroborated Ni and Miledi

  2025-01-13

  

  Subsequently, Palvimaki et al. (1999) corroborated Ni and Miledi's study by demonstrating that treatment with fluoxetine leads to 43% occupancy of the 5-HT2C receptors. Moreover, the affinity of fluoxetine for 5HT2C receptors (Ki 65 nM) is close to its affinity for 5-HT transporters (Ki 33 nM) (Ni a

• Moreover our present work suggests that AXL could

  2025-01-13

  

  Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in Azaserine activated with AXL receptor ligand. A role for AXL in m

• br Experimental section br Acknowledgements br Introduction

  2025-01-10

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming RGDfK in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correlated with

• Additional support for a role of HMGN in

  2025-01-10

  

  Additional support for a role of HMGN1 in enhancing DNA repair comes from studies of transcription-coupled repair (TCR) in human cells. Lesions in the template strand of DNA induced by UV light stall the movement of RNA polymerase II (RNAPII) and interrupt transcription. Removal of these transcripti

• Protein microarrays represent just one

  2025-01-10

  

  Protein microarrays represent just one of a variety of experimental approaches that can be used to generate datasets of relevance to pathway mapping. Other approaches include protein LY 294002 profiling techniques, such as antibody arrays [29], tissue arrays [30] and 2-dimensional gel electrophores

• The protein kinase CK mediated phosphorylation of HMGN

  2025-01-10

  

  The protein kinase CK2-mediated phosphorylation of HMGN1 was implicated to be involved in age-associated amnesia in rats [31]. It was shown that the decreased level of HMGN1 phosphorylation due to the down-regulation of CK2 activity could cause amnesia in aged rats, whereas the treatment with protei

15706 records 23/1048 page Previous Next First page 上5页 2122232425 下5页 Last page