• Materials and methods br Results Assay

  2019-10-22

  

  Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,

• In summary we elucidated the in vitro

  2019-10-22

  

  In summary, we elucidated the in vitro activities of KDM1B in regulation of PC cell proliferation and apoptosis. These studies provided a novel insight into the previously unrecognized roles of KDM1B in human PC cells. We showed for the first time that KDM1B knockdown attenuated proliferation and in

• BEC australia br Acknowledgment This work was supported by t

  2019-10-22

  

  Acknowledgment This work was supported by the Estonian Science Foundation (Grant ETF8862). Introduction In higher eukaryotes ionizing-radiation (IR) induced DNA double-strand breaks (DSB) are primarily repaired by the non-homologous end joining (NHEJ) pathway [1]. Ku, a heterodimeric protein

• Introduction Maintenance of genome integrity is

  2019-10-22

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• In summary these results are

  2019-10-22

  

  In summary, these results are consistent with our hypothesis that chemical nitrosation of BMAA to N-BMAA results in the formation of an alkylating agent. Furthermore, we have shown that N-BMAA is more toxic than BMAA itself. Previously, methylazoxymethanol (MAM), which is also present in the cycad n

• The first purpose of the current study

  2019-10-22

  

  The first purpose of the current study was to characterize a standardized experimental model of postprandial hyperlipidemia in various rodent species. To our knowledge this study provides the most comprehensive and systematic evaluation of rodent models of postprandial hyperlipidemia to date. We ada

• The assessment process is even more difficult when Commercia

  2019-10-22

  

  The assessment process is even more difficult when Commercial-Off-The-Shelf (COTS) components – whose internals are partially or totally unknown – come into play. COTS are being increasingly used by the industry to reduce costs and to shorten development (and possibly deployment) time. However, sinc

• The present study was the first to examine how COMT

  2019-10-22

  

  The present study was the first to examine how COMT genotype and estradiol are associated with IFN-gamma, murine recombinant functioning in healthy postmenopausal women. We hypothesized that with decreased circulating estradiol after menopause, the COMT genotype relationship to cognition would rema

• br Allosteric inhibitors In general candidate drugs

  2019-10-22

  

  Allosteric inhibitors In general, candidate drugs that bind to a GPCR at a site that is distinct (allosteric site) from the binding site of the endogenous agonist (orthosteric site) are attracting increasing attention 39, 42, 58. Allosteric modulators display saturability of their effect, probe d

• Iodoacetyl-LC-Biotin In the brain E can modulate the mitogen

  2019-10-22

  

  In the brain, E2 can modulate the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway, which is involved in the formation of different memory types (Atkins et al., 1998, Blum et al., 1999, Schafe et al., 2000). When the MAPK/ERK signaling pathway is activated,

• Pyruvate dehydrogenase multienzyme complex PDHc catalyzes th

  2019-10-22

  

  Pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative decarboxylation of pyruvate, and subsequently acetylates coenzyme A (CoA) to acetyl-CoA during the tricarboxylic FK 866 hydrochloride receptor metabolic pathway using thiamine diphosphate (ThDP) and Mg2+ as cofactors. PDHc po

• The current study had the following

  2019-10-21

  

  The current study had the following 3 aims: Materials and methods Results Discussion Western Europe, USA/Canada, and Australia have traditionally been the areas in which cochlear Gliotoxin is most common [9], [10]; correspondingly, the most common and well-known validated tests and (re)ha

• EphB promotes tumor growth by stimulating angiogenesis

  2019-10-21

  

  EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of guanidine hydrochloride and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained b

• DNA methylation is associated with transcriptional silencing

  2019-10-21

  

  DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of cancer and other diseases (such as breast and colorectal cancers) [19]. DNA methyltransferases (MTases) are a fami

• Dihydrofolate reductase DHFR is an excellent molecular targe

  2019-10-21

  

  Dihydrofolate reductase (DHFR) is an excellent molecular target for this study because it has been and is currently studied by using different molecular modeling techniques [6], [7], [8], [9]. Kerrigan et al. have reported an interesting review about recent progress in molecular dynamics simulations

15719 records 949/1048 page Previous Next First page 上5页 946947948949950 下5页 Last page