• To validate the identified phosphorylation sites

  2023-09-21

  

  To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T 84 9 mg transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphorylation sites identified

• LEE011 receptor br Adiponectin in prostate cancer PC

  2023-09-21

  

  Adiponectin in prostate cancer PC was documented as the leading type of malignancy in males in the US with respect to both the estimated number of cases (22,800) and deaths (27,540) (Siegel et al., 2016). Studies have reported an association between low APN levels and the progression of PC (Micha

• The central problem in amnesia developing following impairme

  2023-09-21

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• The small fishers with little or no quota who

  2023-09-21

  

  The small fishers with little or no quota who remained relied on quota leasing arrangements to continue their fishing operations. Such arrangements had relatively high transaction costs and by early 2000 it appeared that the demise of the small fisher was imminent [2]. The introduction in 2001 of t

• In this scenario the receptor tyrosine kinase

  2023-09-21

  

  In this scenario, the receptor tyrosine kinase inhibitors (TKI), sunitinib, an anti-angiogenic agent, was tested in phase III trial, leading to a longer progressing free survival when compared to interferon (median: 11 vs. 5mo, respectively, hazard ratio (HR) = 0.42; 95% CI: 0.32–0.54; PISRIB in a

• Autotaxin has been linked to chemoresistance through its abi

  2023-09-21

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer Chlorambucil [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed in p

• Based on its kinetic parameters and quaternary structure R

  2023-09-21

  

  Based on its kinetic parameters and quaternary structure, R. pycnus arginase is a typical ureotelic L-arginase [2]. The Km value of the enzyme was lower than other arginases from other organisms (Table 2), including S. cerevisiae (15.7mM), B. anthracis (10mM), B. caldovelox (3.4mM), human liver (2.3

• As regards LEPR Sun et al showed that the

  2023-09-21

  

  As regards LEPR, Sun et al. showed that the rs1137101-223A > G polymorphism influences the effectiveness of simvastatin on plasma HDL-C levels in CHD patients [35]. In accordance with the results of García-Bermúdez et al., however, no such an association exists between leptin rs2167270 (G > A) polym

• Dopaminergic neurons are vulnerable to oxidative products an

  2023-09-21

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial neostigmine mechanism of action are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial

• To the best of our knowledge only cases of an

  2023-09-21

  

  To the best of our knowledge, only 3 cases of an E196K mutation have been described since it was first identified in 2000 [15], [16], [17], although 5 cases, accounting for 1.1% of all genetic TSE cases, were reported with no precise data on the clinical phenotypes in the EUROCJD collaborative surve

• A phase I trial has recently evaluated enzalutamide an

  2023-09-21

  

  A phase I trial has recently evaluated enzalutamide, an anti-androgen agent, in patients with ER- and AR-positive advanced BC to estimate safety and tolerability of enzalutamide therapy alone or in association to anastrozole, exemestane or fulvestrant [65]. The results of major clinical trials with

• For the first series we

  2023-09-20

  

  For the first series we decided to verify the effects induced, on the ALR2 inhibitory properties, of an additional steric hindrance on the carbon in α position with respect to the carboxylic group, by introducing a methyl group (R2=Me). Therefore, we synthesized a series of new α-alanine derivatives

• Interest in natural products has

  2023-09-20

  

  Interest in natural products has led to the study of plant extracts as sources of ARIs. However, chemical complexity of natural extracts makes the identification of ARIs challenging and time-consuming. Identification of bioactive compounds with the desired biological effect from natural products, co

• Interestingly our transgenic mouse model with macrophages ex

  2023-09-20

  

  Interestingly, our transgenic mouse model with macrophages expressing AdipoR1 showed not only improved insulin sensitivity and inflammation in skeletal muscle and adipose tissues, but fat mass, macrophage and plasma lipid accumulation and foam cell formation was also favorably reduced resulting from

• The difference in the mean values of serum ADA in

  2023-09-20

  

  The difference in the mean values of serum ADA in sputum positive PTB and controls was found to be highly significant (P Discussion Tuberculosis is a major health problem in India, and out of all its forms PTB is the commonest. A definite diagnosis of PTB can be made with the presence of ulixertin

15884 records 277/1059 page Previous Next First page 上5页 276277278279280 下5页 Last page